MK-0626 | DPP-4 inhibitor | Probechem Biochemicals

Chemical Structure : MK-0626

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MK-0626 (MK-626)

货号: PC-49042Not For Human Use, Lab Use Only.

MK-0626 (MK-626) is a potent, selective and orally active DPP-4 inhibitor (IC50=6.3 nM) with excellent selectivity.

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生物&药学活性

MK-0626 (MK-626) is a potent, selective and orally active DPP-4 inhibitor (IC50=6.3 nM) with excellent selectivity.
MK-0626 attenuates hepatic steatosis through enhancing AMPK activity, inhibiting hepatic lipogenic gene expression, enhancing triglyceride secretion from liver and increasing serum adiponectin levels in ob/ob mice.
MK-0626 significantly increased the mRNA expression of PPARα and microsomal triglyceride transfer protein but significantly reduced sterol regulatory element binding transcription factor-1c, fatty acid synthase and stearoyl-CoA desaturase-1.

物理化学性质&存储条件

分子量	442.47
分子式	C22H24F2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-3-Amino-4-(3,3-Difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide

参考文献

1. Sangle GV, et al. Endocrinology. 2012 Feb;153(2):564-73.

2. Tatsuya Ohyama, et al. World J Gastroenterol. 2014 Nov 21;20(43):16227-35.

3. Edmondson SD. J Med Chem. 2006;49:3614–3627.

MK-0626 (MK-626)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-0626 (MK-626)

生物&药学活性

物理化学性质&存储条件

参考文献

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