MK-0536 |CAS:865298-81-3 Probechem Biochemicals

Chemical Structure : MK-0536

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MK-0536 (MK 0536;MK0536)

货号: PC-60405Not For Human Use, Lab Use Only.

MK-0536 is a potent HIV-1 integrase strand transfer inhibitor with IC50 of 33 nM, 9.5 nM, 40 nM, 20 nM and 237 nM for wt IN, IN Y143R, IN N155H, G118R and IN G140S-Q148H, respectively.

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生物&药学活性

MK-0536 is a potent HIV-1 integrase strand transfer inhibitor with IC50 of 33 nM, 9.5 nM, 40 nM, 20 nM and 237 nM for wt IN, IN Y143R, IN N155H, G118R and IN G140S-Q148H, respectively.
MK-0536 shows antiviral activities against RAL-resistant viruses with IC50 of 17/6.0/15/20/77 nM in the cell-based assay for WT, IN Y143R, IN N155H, G118R and IN G140S-Q148H viruses.

物理化学性质&存储条件

分子量	407.826
分子式	C19H19ClFN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3-chloro-4-fluorobenzyl)-4-hydroxy-N,N,2-trimethyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide

参考文献

1. Métifiot M, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5127-33.

2. Pandey KK, et al. J Biol Chem. 2014 Jul 11;289(28):19648-58.

3. Johnson BC, et al. Antimicrob Agents Chemother. 2012 Jan;56(1):411-9.

MK-0536 (MK 0536;MK0536)

生物&药学活性

物理化学性质&存储条件

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MK-0536 (MK 0536;MK0536)

生物&药学活性

物理化学性质&存储条件

参考文献

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