MK-0448 |CAS:875562-81-5 Probechem Biochemicals

Chemical Structure : MK-0448

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MK-0448 (MK0448)

货号: PC-62816Not For Human Use, Lab Use Only.

MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.

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生物&药学活性

MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.
MK-0448 also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61 nM, respectively.
MK-0448 displays >70-fold concentration than inhibition of IKur.
MK-0448 significantly causes prolongation of the atrial refractory period in normal anesthetized dogs.

物理化学性质&存储条件

分子量	448.516
分子式	C24H21FN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfon- amide

参考文献

1. Pavri BB, et al. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1193-201.

2. Loose S, et al. Front Pharmacol. 2014 Mar 4;5:26.

3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069.

MK-0448 (MK0448)

生物&药学活性

物理化学性质&存储条件

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MK-0448 (MK0448)

生物&药学活性

物理化学性质&存储条件

参考文献

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