MK-0429 |CAS:227963-15-7 Probechem Biochemicals

Chemical Structure : MK-0429

CAS No.: 227963-15-7

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MK-0429 (MK0429, L-000845704)

货号: PC-62001Not For Human Use, Lab Use Only.

MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay.

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5 mg	￥3580	In stock
10 mg	￥5280	In stock
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生物&药学活性

MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay.
MK-0429 displays approximately 100-fold selectivity for αvβ3 over αvβ5 (IC50=10 nM), and no significant activity for the fibrinogen receptor αIIBβ3 (IC50>30 uM).
MK-0429 shows activity in different animal models of bone turnover and has potentiation for the prevention and treatment of osteoporosis.
MK-0429 also reduces melanoma metastasis both in vitro and in vivo.

物理化学性质&存储条件

分子量	439.51
分子式	C23H29N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid

参考文献

1. Hutchinson JH, et al. J Med Chem. 2003 Oct 23;46(22):4790-8.

2. Pickarski M, et al. Oncol Rep. 2015 Jun;33(6):2737-45.

3. Zhou X, et al. Pharmacol Res Perspect. 2017 Oct;5(5).

MK-0429 (MK0429, L-000845704)

生物&药学活性

物理化学性质&存储条件

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MK-0429 (MK0429, L-000845704)

生物&药学活性

物理化学性质&存储条件

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