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首页-小分子抑制剂&激动剂-Others-Other Targets-MK-0159
MK-0159

Chemical Structure : MK-0159

CAS No.: 2641484-61-7

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MK-0159 (MK0159)

货号: PC-47057Not For Human Use, Lab Use Only.

MK-0159 is a highly potent, orally bioavailable CD38 enzymatic inhibitor with IC50 of 3 nM (murine CD38) in in vitro assays.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-0159 is a highly potent, orally bioavailable CD38 enzymatic inhibitor with IC50 of 3 nM (murine CD38) in in vitro assays.
MK-0159 showed strong protection from myocardial damage upon cardiac I/R injury compared to those treated with NAD+ precursors (nicotinamide riboside) or the known CD38 inhibitor, 78c.

物理化学性质&存储条件

分子量 400.497
分子式 C20H24N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide

参考文献

1. Bharat Lagu, et al. J Med Chem. 2022 Jun 28. doi: 10.1021/acs.jmedchem.2c00688.

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