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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoacylglycerol Lipase (MAGL)-MJN110
MJN110

Chemical Structure : MJN110

CAS No.: 1438416-21-7

MJN110 (MJN 110, MJN-110)

货号: PC-60707Not For Human Use, Lab Use Only.

MJN110 (MJN-110) is a potent, selective, and orally active MAGL inhibitor with IC50 of 2.1 nM (2-AG hydrolysis).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MJN110 (MJN-110) is a potent, selective, and orally active MAGL inhibitor with IC50 of 2.1 nM (2-AG hydrolysis).
MJN110 wekaly inhibits ABHD6, with excellent selectivity over FAAH and other serine hydrolases.
MJN110 inactivates hMAGL with IC50 of 9.1 nM, attenuates established mechanical allodynia in rat model of diabetic neuropathy.

物理化学性质&存储条件

分子量 462.327
分子式 C22H21Cl2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylat

参考文献

1. Niphakis MJ, et al. ACS Chem Neurosci. 2013 Sep 18;4(9):1322-32.

2. Parker LA, et al. Psychopharmacology (Berl). 2015 Feb;232(3):583-93.

3. Ignatowska-Jankowska B, J Pharmacol Exp Ther. 2015 May;353(2):424-32. et al.

4. Wilkerson JL, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):145-56.

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