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MIV 150

Chemical Structure : MIV 150

CAS No.: 231957-54-3

MIV 150 (PC-815;MIV150)

货号: PC-61409Not For Human Use, Lab Use Only.

MIV 150 (PC-815) is a high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MIV 150 (PC-815) is a high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.
    MIV 150 possesses poor oral bioavailability, and demonstrates efficacy when formulated as a topical microbicide (PC-815: Carrageenan gel formulation).

    物理化学性质&存储条件

    分子量 368.4
    分子式 C19H17FN4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(5-Cyano-2-pyridinyl)-N'-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]urea

    参考文献

    1. Geitmann M, et al. J Med Chem. 2006 Apr 20;49(8):2367-74.

    2. Fernández-Romero JA, et al. Sex Transm Dis. 2007 Jan;34(1):9-14.

    3. Singer R, et al. Sci Transl Med. 2012 Sep 5;4(150):150ra123.

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