MIV-6R |CAS:1560968-55-9 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MIV-6R

Chemical Structure : MIV-6R

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MIV-6R (menin-MLL inhibitor)

货号: PC-70002Not For Human Use, Lab Use Only.

MIV-6R is a potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MIV-6R is a potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM.
MIV-6R demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs.

物理化学性质&存储条件

分子量	417.5863
分子式	C27H35N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(3-(4-(amino(cyclopentyl)(phenyl)methyl)piperidin-1-yl)propoxy)benzonitrile

参考文献

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

2. He S, et al. J Med Chem. 2014 Feb 27;57(4):1543-56.

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MIV-6R (menin-MLL inhibitor)

生物&药学活性

物理化学性质&存储条件

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MIV-6R (menin-MLL inhibitor)

生物&药学活性

物理化学性质&存储条件

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