MIV-247 |CAS:1352817-76-5 Probechem Biochemicals

Chemical Structure : MIV-247

加入收藏

MIV-247 (MIV 247;MIV247)

货号: PC-60705Not For Human Use, Lab Use Only.

MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).
MIV-247 displays high selectivity (>200-fold) overs other related cathepsins, inhibits mouse and cynomolgus monkey cathepsin S with Ki of 4.5 and 7.2 nM, respectively.
MIV-247 attenuates mechanical allodynia alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects in mouse model of neuropathic pain.

物理化学性质&存储条件

分子量	391.391
分子式	C17H24F3N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(2-amino-2-oxoacetyl)cyclobutyl)-2-(2,2-difluoropropanamido)-3-(1-fluorocyclopentyl)propanamide

参考文献

1. Hewitt E, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96.

MIV-247 (MIV 247;MIV247)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MIV-247 (MIV 247;MIV247)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.