MIR17PTi

Chemical Structure : MIR17PTi

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货号: PC-35397Not For Human Use, Lab Use Only.

MIR17PTi is a novel LNA gapmeR antisense oligonucleotide (LNA-ASO), first-in-class inhibitor of pri-mir-17-92.

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生物&药学活性

MIR17PTi is a novel LNA gapmeR antisense oligonucleotide (LNA-ASO), first-in-class inhibitor of pri-mir-17-92; impairs the proliferation of several cancer cell lines established from both solid and hematologic tumors by on-target antisense activity, and more effectively as compared to miR-17-92s inhibitors; triggers apoptosis via impairment of homeostatic MYC/miR-17-92 feed-forward loops (FFLs) in patient-derived MM cells, induces MYC-dependent synthetic lethality; exerts strong in vivo anti-tumor activity in NOD-SCID mice bearing clinically relevant models of MM.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5'-TACTTGCTTGGCTT-3'

参考文献

1. Morelli E, et al. Blood. 2018 Jul 11. pii: blood-2018-03-836601.

MIR17PTi

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MIR17PTi

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