MIPS521 |CAS:1146188-19-3 Probechem Biochemicals

Chemical Structure : MIPS521

CAS No.: 1146188-19-3

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MIPS521 (MIPS-521)

货号: PC-38014Not For Human Use, Lab Use Only.

MIPS521 (MIPS-521) is a potent, positive allosteric modulator (PAM) of adenosine A1 receptor (A1AR).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4680	In stock
200 mg		Get quote

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生物&药学活性

MIPS521 (MIPS-521) is a potent, positive allosteric modulator (PAM) of adenosine A1 receptor (A1AR).
MIPS521 is more potent than VCP171 in reducing eEPSCs in spinal cord from nerve-injured animals, with a pEC50 of 6.9 in electrophysiological recordings of dorsal horn neurons.
MIPS521 displays in vivo analgesic efficacy through modulation of elevated endogenous adenosine (ADO) that occurs in rat spinal cord in neuropathic pain states.
The maximal MIPS521-induced decrease in synaptic current amplitude is significantly greater in nerve-injured animals compared with sham surgery controls indicating a tissue- and context-specific sensitivity to differences in localised ADO tone in the disease models.

物理化学性质&存储条件

分子量	449.7954
分子式	C19H10ClF6NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-Amino-4-(3,5-bis(trifluoromethyl)phenyl)thien-3-yl)(4-chlorophenyl)methanone

参考文献

1. Draper-Joyce CJ, et al. Nature. 2021 Sep;597(7877):571-576.

MIPS521 (MIPS-521)

生物&药学活性

物理化学性质&存储条件

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MIPS521 (MIPS-521)

生物&药学活性

物理化学性质&存储条件

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