MIPO

Chemical Structure : MIPO

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货号: PC-27195Not For Human Use, Lab Use Only.

MIPO is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 7.72 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.8 uM and 19.7 uM.

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生物&药学活性

MIPO is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 7.72 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.8 uM and 19.7 uM.
MIPO reduces NEK9 mRNA and protein levels in Huh-7 and Hep3b cells, NEK9 overexpression partially rescued the inhibitory effects of MIPO, but not NEK2 or NEK6.
MIPO suppresses NEK9-driven tumour growth and restore antitumour immunity in vivo, restores CD8+ T cell antitumour activity.
Combining MIPO with PD-L1 blocker CA-170 synergistically enhances antitumour immunity in HCC.

物理化学性质&存储条件

分子量	392.52
分子式	C22H24N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(thiophen-2-yl)-1-(3-(2-(m-tolylamino)pyrimidin-4-yl)piperidin-1-yl)ethan-1-one

参考文献

1. Lu G, et al. Gut. 2026 Jun 25:gutjnl-2026-338449.

MIPO

生物&药学活性

物理化学性质&存储条件

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MIPO

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物理化学性质&存储条件

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