MIND-4 |CAS:1639965-26-6 Probechem Biochemicals

Chemical Structure : MIND-4

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MIND-4 (MIND4;MIND 4)

货号: PC-61906Not For Human Use, Lab Use Only.

MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway.

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生物&药学活性

MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway.
MIND-4 upregulates the acetylation of nuclear H3 histone substrates lysine-56 and -27 in wild-type primary cortical neurons (DIV11) without effect on lysine-14 of H3 histone, induces transcriptional activation of the NRF2 pathway in HD and wild-type neuronal cells.
MIND-4 significantly protects against mHTTex1-induced neurodegeneration in HD models.

物理化学性质&存储条件

分子量	455.492
分子式	C24H17N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-nitro-8-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)quinoline

参考文献

1. Quinti L, et al. Cell Chem Biol. 2016 Jul 21;23(7):849-61.

MIND-4 (MIND4;MIND 4)

生物&药学活性

物理化学性质&存储条件

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MIND-4 (MIND4;MIND 4)

生物&药学活性

物理化学性质&存储条件

参考文献

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