MIF2 inhibitor 5d

Chemical Structure : MIF2 inhibitor 5d

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货号: PC-20214Not For Human Use, Lab Use Only.

MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF.
MIF2 inhibitor 5d suppresses the proliferation of non-small cell lung cancer cells in two-dimensional (2D) and three-dimensional (3D) cell cultures, by the induction of cell cycle arrest via deactivation of the mitogen-activated protein kinase (MAPK) pathway

物理化学性质&存储条件

分子量	480.51
分子式	C26H19F3N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-methyl-3-(1-(naphthalen-1-yl)ethyl)-6-(3-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

参考文献

1. Zhangping Xiao, et al. J Med Chem. 2022 Feb 10;65(3):2059-2077.