MIDI | Mitochondrial fission inhibitor | Probechem Biochemicals

Chemical Structure : MIDI

CAS No.: 348145-43-7

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MIDI (Mitochondrial division inhibitor)

货号: PC-20116Not For Human Use, Lab Use Only.

MIDI (Mitochondrial division inhibitor) is a potent, covalent mitochondrial fission inhibitor, interacts with DRP1-C367 to block mitochondrial fission.

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10 mg	￥3980	In stock
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生物&药学活性

MIDI (Mitochondrial division inhibitor) is a potent, covalent mitochondrial fission inhibitor, interacts with DRP1-C367 to block mitochondrial fission.
MIDI potently blocks mitochondrial fragmentation induced by mitochondrial toxins and restores mitochondrial morphology in fusion-defective cells carrying pathogenic mitofusin and OPA1 mutations.
MIDI does not affect DRP1 tetramerization nor DRP1 GTPase activity but does block DRP1 recruitment to mitochondria.
MIDI targets DRP1 interaction with multiple receptors (MFF, MiD49, and MiD51) via covalent interaction with DRP1-C367.

物理化学性质&存储条件

分子量	340.38
分子式	C22H16N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,2'E)-1,1'-(1,4-phenylene)bis(3-(pyridin-3-yl)prop-2-en-1-one)

参考文献

1. Yang J, et al. Cell Chem Biol. 2023 Feb 17:S2451-9456(23)00033-8.

MIDI (Mitochondrial division inhibitor)

生物&药学活性

物理化学性质&存储条件

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MIDI (Mitochondrial division inhibitor)

生物&药学活性

物理化学性质&存储条件

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