MI 219 |CAS:908027-55-4 Probechem Biochemicals

Chemical Structure : MI 219

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MI 219 (MI219, MI-219)

货号: PC-62086Not For Human Use, Lab Use Only.

MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.

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生物&药学活性

MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.
MI 219 disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells.
MI 219 inhibits tumor growth in mouse xenograft models.

物理化学性质&存储条件

分子量	552.468
分子式	C27H32Cl2FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-1,2-dihydro-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide

参考文献

1. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8.

2. Peterson LF, et al. Leukemia. 2011 May;25(5):761-9.

3. Feng FY, et al. Neoplasia. 2016 Apr;18(4):213-22.

MI 219 (MI219, MI-219)

生物&药学活性

物理化学性质&存储条件

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MI 219 (MI219, MI-219)

生物&药学活性

物理化学性质&存储条件

参考文献

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