MI-743

Chemical Structure : MI-743

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货号: PC-27894Not For Human Use, Lab Use Only.

MI-743 is a potent, specific inhibitor of human mutT homolog 1 (MTH1, Nudix hydrolase 1, NUDT1) with IC50 of 91.44 nM.

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100 mg		Get quote

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生物&药学活性

MI-743 is a potent, specific inhibitor of human mutT homolog 1 (MTH1, Nudix hydrolase 1, NUDT1) with IC50 of 91.44 nM.
MI-743 causes cytotoxicity and induces 8-oxo-dG accumulation, DNA damage and apoptosis in MGC-803 and HGC-27 cells.
MI-743 (40 mg/kg, once a day) is efficacious in inhibiting the MGC-803 cells growth in vivo without obvious global toxicity.
MI-743 induced gastric cancer cell apoptosis.

物理化学性质&存储条件

分子量	408.45
分子式	C18H12N6O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-cyano-6-(2-oxo-2H-chromen-6-yl)-2-(prop-2-yn-1-ylthio)pyrimidin-4-yl)hydrazine-1-carbothioamide

参考文献

1. Wenjuan Zhou, et al. Cell Death Dis. 2019 Jun 4;10(6):434.

MI-743

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物理化学性质&存储条件

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MI-743

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物理化学性质&存储条件

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