MI-503 |CAS:1857417-13-0 Probechem Biochemicals

Chemical Structure : MI-503

CAS No.: 1857417-13-0

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MI-503 (MI 503;MI503)

货号: PC-45092Not For Human Use, Lab Use Only.

MI-503 (MI 503) is a highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MI-503 (MI 503) is a highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM.
MI-503 effectively induces differentiation of MLL leukemia cells and and substantially increases expression of CD11b, also reduces expression of Hoxa9 and Meis1.
MI-503 induces marked anti-proliferative effects in MV4;11 cells with GI50 of 200 nM.
MI-503 blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden in mouse models.

物理化学性质&存储条件

分子量	564.6278
分子式	C28H27F3N8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((1H-pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile

参考文献

1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.

2. Svoboda LK, et al. Oncotarget. 2017 Jan 3;8(1):458-471.

MI-503 (MI 503;MI503)

生物&药学活性

物理化学性质&存储条件

参考文献

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MI-503 (MI 503;MI503)

生物&药学活性

物理化学性质&存储条件

参考文献

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