MI-3 | menin-MLL inhibitor | Probechem Biochemicals

Chemical Structure : MI-3

CAS No.: 1271738-59-0

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MI-3 (Menin-MLL inhibitor MI-3)

货号: PC-38602Not For Human Use, Lab Use Only.

MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.
MI-3 inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL with IC50 of 5 uM for both.
MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

物理化学性质&存储条件

分子量	375.553
分子式	C18H25N5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine

参考文献

1. Jolanta Grembecka, et al. Nat Chem Biol. 2012 Jan 29;8(3):277-84.

MI-3 (Menin-MLL inhibitor MI-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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MI-3 (Menin-MLL inhibitor MI-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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