MI-223 |CAS:907166-59-0 Probechem Biochemicals

Chemical Structure : MI-223

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MI-223 (NSC 320223, MI223)

货号: PC-62743Not For Human Use, Lab Use Only.

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.

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生物&药学活性

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.
MI-223 not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
MI-223 exhibits a strong synergy against lung cancer in vivo combined with Olaparib.

物理化学性质&存储条件

分子量	419.865
分子式	C23H18ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-chlorophenyl)-3-[[(Z)-(5-ethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]quinazolin-4-one

参考文献

1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.

MI-223 (NSC 320223, MI223)

生物&药学活性

物理化学性质&存储条件

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MI-223 (NSC 320223, MI223)

生物&药学活性

物理化学性质&存储条件

参考文献

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