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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-MI-181
MI-181

Chemical Structure : MI-181

CAS No.: 897287-01-3

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MI-181 (Mitotic inhibitor-181)

货号: PC-22895Not For Human Use, Lab Use Only.

MI-181 (Mitotic inhibitor-181) is a potent M-phase inhibitor with mitotic arrest IC50 of 23 nM and cell death IC50 of 17 nM, inhibits tubulin polymerization and modulates cilia length and biogenesis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MI-181 (Mitotic inhibitor-181) is a potent M-phase inhibitor with mitotic arrest IC50 of 23 nM and cell death IC50 of 17 nM, inhibits tubulin polymerization and modulates cilia length and biogenesis.
MI-181 is a potent cell cycle-specific inhibitor, which arrested cells in mitosis, activated the SAC, and induced an apoptotic cell death with faster kinetics than taxol.
MI-181 is active in a broad array of cancers, especially melanomas (BRAFV600E melanomas, IC50=18-90 nM).
MI-181 is effective at rescuing cilia length and ciliation defects in cells that had been treated with the intraflagellar transport inhibitor Ciliobrevin D or the O-GlcNAc transferase inhibitor OSMI-1.
MI-181 induces an increase in cilia length and restores ciliation in cells with compromised shortened cilia at low nanomolar concentrations.
MI-181 restores ciliation and cilia length in cells with a compromised IFT system.

物理化学性质&存储条件

分子量 266.36
分子式 C16H14N2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-5,6-dimethyl-2-(2-(pyridin-3-yl)vinyl)benzo[d]thiazole

参考文献

1. Senese S, et al. Cell Death Dis. 2014 Oct 16;5(10):e1462.

2. Gholkar AA, et al. ACS Chem Biol. 2024 Aug 6. doi: 10.1021/acschembio.4c00186.

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