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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MI-136
MI-136

Chemical Structure : MI-136

CAS No.: 1628316-74-4

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MI-136 (MI 136;MI136)

货号: PC-45602Not For Human Use, Lab Use Only.

MI-136 is a potent Menin-MLL interaction inhibitor with IC50 of 31 nM.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2480 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MI-136 is a potent Menin-MLL interaction inhibitor with IC50 of 31 nM.
MI-136 demonstrates potent inhibitory activity and strong binding affinity to menin.

物理化学性质&存储条件

分子量 470.5132
分子式 C23H21F3N6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
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Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

参考文献

1. Borkin D, et al. J Med Chem. 2016 Feb 11;59(3):892-913.

2. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.

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