MHY5535 | PPARα antagonist | Probechem Biochemicals

Chemical Structure : MHY5535

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MHY5535 (MHY-5535)

货号: PC-27669Not For Human Use, Lab Use Only.

MHY5535 is a potent PPARα antagonist, inhibits PPARα transcriptional activity with IC50 of 0.54 uM, effectively reduces ovarian cancer stem cells (CSCs) viability and self-renewal.

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生物&药学活性

MHY5535 is a potent PPARα antagonist, inhibits PPARα transcriptional activity with IC50 of 0.54 uM, effectively reduces ovarian cancer stem cells (CSCs) viability and self-renewal.
MHY5535 inhibits ovarian CSC viability (IC50=6.22 uM) and stemness through PPARα antagonism.
MHY5535 impairs mitochondrial energy metabolism and fatty acid dependency in ovarian CSCs.
MHY5535 synergizes with standard chemotherapy to eradicate ovarian CSCs.
MHY5535 and doxorubicin combination therapy suppresses tumor growth in an ovarian CSC xenograft model.

物理化学性质&存储条件

分子量	595.71
分子式	C34H33N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-benzylpiperidin-4-yl)-2-((2-(4-(phenylsulfonamido)phenyl)benzofuran-5-yl)oxy)acetamide

参考文献

1. Min Joo Shin, et al. Biomed Pharmacother. 2026 Aug 12:203:119842.

MHY5535 (MHY-5535)

生物&药学活性

物理化学性质&存储条件

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MHY5535 (MHY-5535)

生物&药学活性

物理化学性质&存储条件

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