MFT251 (MFT-251)

Chemical Structure : MFT251

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货号: PC-27849Not For Human Use, Lab Use Only.

MFT251 is a specific, direct small molecule TANK-binding kinase 1 (TBK1) activator, induces robust type I IFN responses, directly engages TBK1, leading to IRF3 phosphorylation and selective activation of IFN-stimulated gene programs.

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生物&药学活性

MFT251 is a specific, direct small molecule TANK-binding kinase 1 (TBK1) activator, induces robust type I IFN responses, directly engages TBK1, leading to IRF3 phosphorylation and selective activation of IFN-stimulated gene programs.
MFT251 confers host-directed antiviral activity against coronaviruses, including SARS-CoV-2, through induction of interferon-stimulated genes.
MFT251 also modulates the tumor immune microenvironment toward an immunologically active state, characterized by enhanced antigen presentation and increased infiltration of cytotoxic T cells, resulting in augmented antitumor immune responses in vivo.

物理化学性质&存储条件

分子量	408.43
分子式	C21H16N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-((4-(6-methoxybenzofuran-2-yl)thiazol-2-yl)carbamoyl)benzoate

参考文献

1. Jeong K, et al. Mol Ther. 2026 Aug 25:S1525-0016(26)00718-5.

MFT251 (MFT-251)

生物&药学活性

物理化学性质&存储条件

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MFT251 (MFT-251)

生物&药学活性

物理化学性质&存储条件

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