MFN2 agonist B-A l |CAS:2230047-87-5 Probechem Biochemicals

Chemical Structure : MFN2 agonist B-A l

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MFN2 agonist B-A l (MFN2 agonist B-A/l)

货号: PC-35582Not For Human Use, Lab Use Only.

MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM.

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生物&药学活性

MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM.
MFN2 agonist B-A l potently stimulates mitochondrial fusion in MFN2-deficient cells, competed for minipeptide binding at the MFN2 HR2 interaction site, correct mitochondrial damage induced by nonfunctioning MFN2 mutants by activating endogenous mitofusins by amelioration of mitochondrial dysmotility, fragmentation, depolarization, and clumping.
MFN2 agonist B-A l normalizes axonal mitochondrial trafficking within sciatic nerves of MFN2 Thr105→Met105 mice.

物理化学性质&存储条件

分子量	399.557
分子式	C21H29N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((5-cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-3-(2-methylcyclohexyl)urea

参考文献

1. Rocha AG, et al. Science. 2018 Apr 20;360(6386):336-341.

MFN2 agonist B-A l (MFN2 agonist B-A/l)

生物&药学活性

物理化学性质&存储条件

参考文献

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MFN2 agonist B-A l (MFN2 agonist B-A/l)

生物&药学活性

物理化学性质&存储条件

参考文献

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