欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-MFI8
MFI8

Chemical Structure : MFI8

CAS No.: 694488-83-0

加入收藏

MFI8 (Mitochondrial Fusion Inhibitor 8)

货号: PC-49095Not For Human Use, Lab Use Only.

MFI8 (Mitochondrial Fusion Inhibitor 8) is a small molecule inhibitor of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively decreases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 4.8 uM.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MFI8 (Mitochondrial Fusion Inhibitor 8) is a small molecule inhibitor of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively decreases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 4.8 uM.
MFI8 shows a comparable concentration-dependent reduction of the mitochondrial aspect ratio to that of 398-418 Gly peptide.
MFI8 inhibits mitochondrial fusion in a MFN1/2 dependent manner, binds to the HR2 domain of MFN2 with KD of 7.6 uM in microscale thermophoresis (MST) assay.
MFI8 induces mitochondrial outer membrane permeabilization (MOMP) and subsequent activation of caspases 3/7, induces DNA damage in U2OS cells.
MFI8 reduced respiration and mitochondrial ATP production in WT but not in Mfn1/Mfn2 DKO MEFs, does not alter the ratio of state III/state II respiration of isolated mitochondria.
MFI8 induces minority MOMP and cytochrome c release leading to caspase 3/7 activation, sensitize cells to apoptotic cell death in combination with SMAC-mimetic BV6.

物理化学性质&存储条件

分子量 275.776
分子式 C16H18ClNO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-2-(1-((2,3-dimethylphenyl)amino)ethyl)phenol

参考文献

1. Zacharioudakis E, et al. Nat Commun. 2022 Jul 7;13(1):3775.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: