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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-MF498
MF498

Chemical Structure : MF498

CAS No.: 915191-42-3

MF498 (MF-498)

货号: PC-42699Not For Human Use, Lab Use Only.

MF498 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist with Ki of 0.74 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MF498 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist with Ki of 0.74 nM.
MF498 inhibits PGE2-induced cAMP accumulation in HEK293 cells stably expressing human EP4 receptor with IC50 of 1.7 nM.
MF498 inhibits inflammation in adjuvant-induced arthritis (AIA) model.

物理化学性质&存储条件

分子量 603.6853
分子式 C32H33N3O7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Benzeneacetamide, N-[[[4-(5,9-diethoxy-6,8-dihydro-6-oxo-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy-

参考文献

1. Clark P. et al. J Pharmacol Exp Ther. 2008 May;325(2):425-34.

2. Burch JD, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2048-54.

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