MF-766 | EP4 antagonist | Probechem Biochemicals

Chemical Structure : MF-766

CAS No.: 1050656-06-8

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MF-766 (MF766, MF 766)

货号: PC-36059Not For Human Use, Lab Use Only.

MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM).

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM).
MF-766 behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay.
MF-766 exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM).
MF-766 demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.

物理化学性质&存储条件

分子量	478.471
分子式	C27H21F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxamido)cyclopropyl)benzoic acid

参考文献

1. Colucci J, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3.

MF-766 (MF766, MF 766)

生物&药学活性

物理化学性质&存储条件

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MF-766 (MF766, MF 766)

生物&药学活性

物理化学性质&存储条件

参考文献

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