MF-438 | SCD1 inhibitor | Probechem Biochemicals

Chemical Structure : MF-438

CAS No.: 921605-87-0

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MF-438 (MF438)

货号: PC-20379Not For Human Use, Lab Use Only.

MF-438 (MF438) is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MF-438 (MF438) is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM.
Co-treatment with cisplatin and the SCD1 inhibitor MF-438 reverts upregulation of lung cancer CSCs markers, strongly synergizes in the inhibition of 3D spheroids formation and induces CSCs apoptosis.
MF-438 exhibits good pharmacokinetics and metabolic stability.
MF-438 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma.

物理化学性质&存储条件

分子量	421.44
分子式	C19H18F3N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine

参考文献

1. Léger S, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.

2. Pisanu ME, et al. Cancer Lett. 2017 Oct 10;406:93-104.

3. Pisanu ME, et al. J Exp Clin Cancer Res. 2018 Dec 17;37(1):318.

MF-438 (MF438)

生物&药学活性

物理化学性质&存储条件

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MF-438 (MF438)

生物&药学活性

物理化学性质&存储条件

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