MET inhibitor Compound 1 |CAS:1208248-23-0 Probechem Biochemicals

Chemical Structure : MET inhibitor Compound 1

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MET inhibitor Compound 1 (c-Met-IN-16)

货号: PC-60929Not For Human Use, Lab Use Only.

MET inhibitor Compound 1 is a potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively.

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MET inhibitor Compound 1 is a potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively.
MET inhibitor Compound 1 demonstrates potent, broad spectrum activity against MET mutants (V1110I, H1112Y, L1195V, Y1235D, D1228H and M1250T) with IC50 of <1 nM-57 nM, and Y1230 mutants with moderate potency (IC50=25-280 nM).
MET inhibitor Compound 1 displays >50-fold selectivity in a panel of 130 kinases with exception of Fms and TrkA/B/C.
MET inhibitor Compound 1 inhibits MET-dependent tumor cell growth in vivo through decreasing phosphorylaed MET.

物理化学性质&存储条件

分子量	449.426
分子式	C21H17F2N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

参考文献

1. Farrell PJ, et al. Mol Cancer Ther. 2017 Jul;16(7):1269-1278.

MET inhibitor Compound 1 (c-Met-IN-16)

生物&药学活性

物理化学性质&存储条件

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MET inhibitor Compound 1 (c-Met-IN-16)

生物&药学活性

物理化学性质&存储条件

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