METTL9i | METTL9 inhibitor | Probechem Biochemicals

Chemical Structure : METTL9i

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METTL9i (METTL9 inhibitor)

货号: PC-26384Not For Human Use, Lab Use Only.

METTL9i is a first-in-class, highly potent, selective and cell-active methyltransferase METTL9 inhibitor with IC50 of 67 nM.

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250 mg		Get quote

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生物&药学活性

METTL9i is a first-in-class, highly potent, selective and cell-active methyltransferase METTL9 inhibitor with IC50 of 67 nM.
METTL9i exhibits high selectivity for METTL9 relative to other methyltransferases.
METTL9i binds within the S-adenosylmethionine (SAM) binding pocket of METTL9.
METTL9i engages METTL9 and leads to a reduction in global 1-methylhistidine (1-MH) levels in cells, without affecting 3-methylhistidine.
METTL9i displaysthe potent inhibitory activity against pancreatic cancer cells BxPC-3 and PANC-1 with IC50 values of 3.42 µM and 9.92 µM, respectively.

物理化学性质&存储条件

分子量	636.67
分子式	C31H30F2N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(3-(dimethylamino)propoxy)-5-(8-fluoro-4-((3-hydroxyphenyl)amino)quinazolin-6-yl)pyridin-3-yl)-3-fluoro-4-methoxybenzenesulfonamide

参考文献

1. Yao R, et al. Angew Chem Int Ed Engl. 2026 Mar 23:e3642560.