METTL3 inhibitor 54

Chemical Structure : METTL3 inhibitor 54

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货号: PC-21078Not For Human Use, Lab Use Only.

METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.
METTL3 inhibitor 54 displays no activity against METTL1 and METTL16 up to 200 μM.
METTL3 inhibitor 54 shows a GI50 of 6 μM for the MOLM-13 AML cell line.

物理化学性质&存储条件

分子量	590.82
分子式	C37H46N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	OC1(CNC2=C3C=CC(CN4C(C(C)C)C5(CCC5)C4)=CC3=CC=C2)CN(C6=NC=NC(NCC7=CC=CC=C7)=C6)CCC1

参考文献

1. Bedi RK, et al. ACS Bio Med Chem Au. 2023 Jun 14;3(4):359-370.