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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-MET409
MET409

Chemical Structure : MET409

CAS No.: 2244500-76-1

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MET409 (MET-409)

货号: PC-20979Not For Human Use, Lab Use Only.

MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR).
MET409 displays no cross-reactivity against TGR5, pregnane X receptor, vitamin D receptor or PPAR isoforms (α, γ, δ).
MET409 shows potential for treatment of nonalcoholic fatty liver disease.

物理化学性质&存储条件

分子量 515.70
分子式 C32H41N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C([C@@H]1CC[C@H](O)CC1)N(C[C@H]2CC[C@H](C3=CC=C(OC)C(C)=C3)CC2)C4=CC=CC(C5=CN(C)N=C5)=C4

参考文献

1. Stefano Fiorucci, et al. Expert Opin Drug Discov. 2021 Oct;16(10):1193-1208.

2. Harrison SA, et al. J Hepatol. 2021 Jul;75(1):25-33.

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