Chemical Structure : MEN1703
CAS No.: 1616359-00-2
货号: PC-63507Not For Human Use, Lab Use Only.
SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥2480 | In stock | |
5 mg | ¥3980 | In stock | |
10 mg | ¥5980 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
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SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.
SEL24-B489 exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors.
SEL24-B489 decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors.
SEL24-B489 inhibits the growth of a broad panel of AML cell lines in xenograft models.
分子量 | 446.143 | |
分子式 | C15H18Br2N4O2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole |
1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931.
2. Białopiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632.
3. Szydłowski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.
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