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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-Pim-MEN1703
MEN1703

Chemical Structure : MEN1703

CAS No.: 1616359-00-2

MEN1703 (SEL24-B489, SEL24)

货号: PC-63507Not For Human Use, Lab Use Only.

SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.

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5 mg ¥3980 In stock
10 mg ¥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.
SEL24-B489 exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors.
SEL24-B489 decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors.
SEL24-B489 inhibits the growth of a broad panel of AML cell lines in xenograft models.

物理化学性质&存储条件

分子量 446.143
分子式 C15H18Br2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole

参考文献

1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931.

2. Białopiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632.

3. Szydłowski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.

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