MELK inhibitor C1

Chemical Structure : MELK inhibitor C1

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货号: PC-70141Not For Human Use, Lab Use Only.

MELK inhibitor C1 is a potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MELK inhibitor C1 is a potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM.
MELK inhibitor C1 causes mitotic arrest and subsequent cellular apoptosis in vitro.
MELK inhibitor C1 strongly induces tumor cell apoptosis in slice cultures of GBM surgical specimens and attenuates growth of mouse intracranial tumors derived from GSCs.
MELK inhibitor C1 also inhibits Aurora A/B/C (IC50=61/31/124 nM), and Chk1 (IC50=262 nM).
MELK inhibitor C1 is a multi-kinase inhibitor.

物理化学性质&存储条件

分子量	292.338
分子式	C18H16N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-ethyl-3-methoxy-7,10-dihydro-11H-benzo[e]pyrido[4,3-b]indol-11-one

参考文献

1. Minata M, et al. PLoS One. 2014 Apr 16;9(4):e92546.

2. Hoang TM, et al. Cell Cycle. 2009 Mar 1;8(5):765-72.