MELK-T1 | MELK inhibitor | ProbeChem Biochemicals

Chemical Structure : MELK-T1

CAS No.: 1610586-62-3

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MELK-T1 (JNJ-47117096, JNJ 47117096)

货号: PC-70140Not For Human Use, Lab Use Only.

MELK-T1 (JNJ-47117096) is a cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MELK-T1 (JNJ-47117096) is a cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.
MELK-T1 (JNJ-47117096) shows >50% inhibition at 1 uM against 6 kianses in a panel of 235 kinases (Flt3 IC50=18 nM).
MELK-T1 (JNJ-47117096) triggers a rapid and proteasome-dependent degradation of the MELK protein, induces the accumulation of stalled replication forks and DSBs in MCF-7 cells.
MELK-T1 (JNJ-47117096) induces a strong phosphorylation of p53, a prolonged up-regulation of p21 and a down-regulation of FOXM1 target genes.

物理化学性质&存储条件

分子量	362.433
分子式	C21H22N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)benzamide

参考文献

1. Beke L, et al. Biosci Rep. 2015 Oct 2;35(6). pii: e00267.

2. Johnson CN, et al. ACS Med Chem Lett. 2014 May 23;6(1):25-30.

MELK-T1 (JNJ-47117096, JNJ 47117096)

生物&药学活性

物理化学性质&存储条件

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MELK-T1 (JNJ-47117096, JNJ 47117096)

生物&药学活性

物理化学性质&存储条件

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