MEK4 inhibitor 15o

Chemical Structure : MEK4 inhibitor 15o

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货号: PC-72692Not For Human Use, Lab Use Only.

MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM.
MEK4 inhibitor 10e demonstrated significant reduction of phospho-JNK and antiproliferative properties against pancreatic cancer cell lines, molecular inhibition of MEK4 pathway activates the MEK1/2 pathway.
MEK4 inhibitor 10e demonstrated synergistic effects against pancreatic cancer cells with the combination of MEK1/2 inhibitors.

物理化学性质&存储条件

分子量	410.423
分子式	C20H15FN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-(6-fluoro-1H-indazol-3-yl)phenyl)sulfonamido)benzamide

参考文献

1. Kwong AJ, et al. ACS Med Chem Lett. 2021 Sep 15;12(10):1559-1567.