MEISi-3

Chemical Structure : MEISi-3

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货号: PC-27211Not For Human Use, Lab Use Only.

MEISi-3 is a small molecule MEIS2 inhibitor targeting MEIS2 proteins effectively along with MEIS1, exhibits potent growth inhibition with IC50 of 0.1 μM in SK-BR-3 cells.

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生物&药学活性

MEISi-3 is a small molecule MEIS2 inhibitor targeting MEIS2 proteins effectively along with MEIS1, exhibits potent growth inhibition with IC50 of 0.1 μM in SK-BR-3 cells.
MEISi-3 inhibits Meis1 transcript levels and reporter genes, induces downregulation of MEIS2 as well as their downstream targets such as IL17RB, CDH1, EGR2, PAX6.
MEISi-3 is a potent inhibitor in MCF7 cells with an IC50 of 1.27 uM, induces apoptosis and necrosis.

物理化学性质&存储条件

分子量	432.50
分子式	C22H20N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[4-[2-[1,5-dihydro-3-methyl-1-[4-(4-methylphenyl)-2-thiazolyl]-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]phenyl]-

参考文献

1. Fatih Kocabaş, et al. Pharmaceuticals (Basel). 2026 Jun 1;19(6):881.

MEISi-3

生物&药学活性

物理化学性质&存储条件

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MEISi-3

生物&药学活性

物理化学性质&存储条件

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