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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HSV-MEDS433
MEDS433

Chemical Structure : MEDS433

CAS No.: 2241027-61-0

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MEDS433 (MEDS-433)

货号: PC-72691Not For Human Use, Lab Use Only.

MEDS433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MEDS433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range.
MEDS433 targets the de novo pyrimidine biosynthesis.
MEDS433 exhibited highly synergistic antiviral activity when combined with acyclovir and dipyridamole.
MEDS433 is a promising candidate as either single agent or in combination regimens with existing direct-acting anti-HSV drugs.

物理化学性质&存储条件

分子量 401.321
分子式 C20H11F4N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-hydroxy-N-(2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

参考文献

1. Luganini A, et al. Antiviral Res. 2021 May;189:105057.

2. Stefano Sainas, et al. J Med Chem. 2018 Jul 26;61(14):6034-6055.

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