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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-ME0328
ME0328

Chemical Structure : ME0328

CAS No.: 1445251-22-8

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ME0328 (ME-0328)

货号: PC-35508Not For Human Use, Lab Use Only.

ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM.

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10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM.
ME0328 displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10.8 and >30 uM respectively).
ME0328 potentiates vinorelbine sensitization in breast cancer cell lines at the G2/M boundary, also potentiates vinorelbine-induced PARP3 inhibition, mitotic arrest, and apoptosis.

物理化学性质&存储条件

分子量 321.38
分子式 C19H19N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

参考文献

1. Lindgren AE, et al. ACS Chem Biol. 2013 Aug 16;8(8):1698-703.

2. Sharif-Askari B, et al. Breast Cancer Res Treat. 2018 Jul 23. doi: 10.1007/s10549-018-4888-6.

3. Wang H, et al. Cancer Lett. 2017 Jan 28;385:137-143.

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