ME-344 (NV-344) | Mitochondrial inhibitor | Probechem Biochemicals

Chemical Structure : ME-344

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ME-344 (ME344;ME 344;NV-344)

货号: PC-60554Not For Human Use, Lab Use Only.

ME-344 (NV-344) is a novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM, also targets heme oxygenase 1 (HO-1) and disrupts redox homeostasis.

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生物&药学活性

ME-344 (NV-344) is a novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM, also targets heme oxygenase 1 (HO-1) and disrupts redox homeostasis.
ME-344 inhibits oxygen consumption rates, with specific effects on the respiratory chain, causes complex, redox-specific, and mitochondria-targeted effects in lung cancer cells.
ME-344 reduces tumor growth in OCI-AML2 xenograft models.
ME-344 is an active metabolite of NV-128.

物理化学性质&存储条件

分子量	348.40
分子式	C22H20O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol

参考文献

1. Jeyaraju DV, et al. Oncotarget. 2016 Aug 2;7(31):49777-49785.

2. Manevich Y, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):199-208.

3. Lim SC, et al. Am J Cancer Res. 2015 Jan 15;5(2):689-701.

ME-344 (ME344;ME 344;NV-344)

生物&药学活性

物理化学性质&存储条件

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询单

ME-344 (ME344;ME 344;NV-344)

生物&药学活性

物理化学性质&存储条件

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