ME-143 (NV-143) | NADH oxidase inhibitor | Probechem Biochemicals

Chemical Structure : ME-143

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ME-143 (NV-143, ME143)

货号: PC-20714Not For Human Use, Lab Use Only.

ME-143 (NV-143) is a second-generation tumor-specific NADH oxidase inhibitor, binds to purified recombinant ENOX2 with Kd value of 43 nM, shows broad activity against human cancers in vitro and in vivo.

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生物&药学活性

ME-143 (NV-143) is a second-generation tumor-specific NADH oxidase inhibitor, binds to purified recombinant ENOX2 with Kd value of 43 nM, shows broad activity against human cancers in vitro and in vivo.
ME-143 is a more than 10-fold potent inhibitor of DLD1 proliferation than genistein at 3.125 μM.
ME-143 significantly reduced WNT throughput by 65-75% in both the RKO and DLD1 cell lines.
ME-143 alone and in combination with 5FU and oxaliplatin effectively inhibits the WNT/β-catenin pathway in colorectal cancer cells of diverse genetic background.

物理化学性质&存储条件

分子量	334.37
分子式	C21H18O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(7-hydroxychromane-3,4-diyl)diphenol

参考文献

1. Morré DJ, et al. Oncol Res. 2014;22(1):1-12.

2. Pintova S, et al. Anticancer Res. 2017 Apr;37(4):1647-1653.

ME-143 (NV-143, ME143)

生物&药学活性

物理化学性质&存储条件

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ME-143 (NV-143, ME143)

生物&药学活性

物理化学性质&存储条件

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