MDVN-1003 |CAS:2058116-54-2 Probechem Biochemicals

Chemical Structure : MDVN-1003

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MDVN-1003 (MDVN1003;MDVN 1003)

货号: PC-60272Not For Human Use, Lab Use Only.

MDVN-1003 (MDVN1003) is a first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.

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生物&药学活性

MDVN-1003 (MDVN1003) is a first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.
MDVN-1003 inhibits B cell activation upon BCR cross-linking ex vivo and in vivo, induces apoptosis and decreases viability of DOHH-2 cells.
MDVN-1003 shows significant anti-tumor effects in an NHL xenograft model in mice.

物理化学性质&存储条件

分子量	417.45
分子式	C22H20FN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-amino-2,3-dihydro-1H-inden-2-yl)-3-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

参考文献

1. Alfaro J, et al. J Pharmacol Exp Ther. 2017 May;361(2):312-321.

MDVN-1003 (MDVN1003;MDVN 1003)

生物&药学活性

物理化学性质&存储条件

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询单

MDVN-1003 (MDVN1003;MDVN 1003)

生物&药学活性

物理化学性质&存储条件

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