MDP5

Chemical Structure : MDP5

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货号: PC-26515Not For Human Use, Lab Use Only.

MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2.

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生物&药学活性

MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2.
MDP5 significantly inhibits the proliferation in both cell lines with IC50 values of 5.57 μM and 5.14 μM, respectively.
MDP5 inhibits cell cycle progression, colony formation, and apoptosis in MB cells.
MDP5 treatment decreases target gene expression at mRNA and protein levels.
MDP5 (20 mg/kg) decreases xenograft tumor burden in MB xenograft mice.
When combined with the KRAS G12D inhibitor MRTX1133, MDP5 resensitized resistant cancer cells.

物理化学性质&存储条件

分子量	365.39
分子式	C21H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(2,3-dihydrobenzo[b] [1, 4] dioxin-6-yl)-2-morpholino-4H-chromen-4-one

参考文献

1. Sethi B, et al. J Control Release. 2023 Feb;354:80-90.

2. Ghanwatkar Y, et al. Acta Biomater. 2026 Mar;212:637-654.

MDP5

生物&药学活性

物理化学性质&存储条件

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MDP5

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