MDOLL-0229 | SARS-CoV-2 Mac1 inhibitor | Probechem Biochemicals

Chemical Structure : MDOLL-0229

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MDOLL-0229 (MDOLL0229)

货号: PC-21690Not For Human Use, Lab Use Only.

MDOLL-0229 is a selective small molecule inhibitor for SARS-CoV-2 Mac1 with IC50 of 2.1 uM, inhibits coronavirus replication.

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1 g		Get quote

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生物&药学活性

MDOLL-0229 is a selective small molecule inhibitor for SARS-CoV-2 Mac1 with IC50 of 2.1 uM, inhibits coronavirus replication.
MDOLL-0229 is generally selective for CoV Mac1 proteins after profiling for activity against a panel of viral and human ADP-ribose binding proteins.
MDOLL-0229 inhibits replication of both MHVa prototype CoV, and SARS-CoV-2.
MDOLL-0229 is the first Mac1 targeted small molecule demonstrated to inhibit coronavirus replication in cell models.

物理化学性质&存储条件

分子量	393.50
分子式	C20H27NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-2-((3-(methoxycarbonyl)-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)carbamoyl)cyclohexane-1-carboxylic acid

参考文献

1. Sarah Wazir, et al. bioRxiv. 2023 Dec 27:2023.08.28.555062.

MDOLL-0229 (MDOLL0229)

生物&药学活性

物理化学性质&存储条件

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MDOLL-0229 (MDOLL0229)

生物&药学活性

物理化学性质&存储条件

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