MDL28170 | Calpain inhibitor | Probechem Biochemicals

Chemical Structure : MDL28170

CAS No.: 88191-84-8

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MDL28170 (MDL-28170)

货号: PC-20599Not For Human Use, Lab Use Only.

MDL28170 is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain, also blocks γ-secretase activity.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

MDL28170 is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain, also blocks γ-secretase activity.
MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization.
MDL-28170 dose-dependently inhibits brain cysteine proteinase activity with Ki of 10 nM.
MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in vivo.
MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.

物理化学性质&存储条件

分子量	382.46
分子式	C22H26N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzyl ((2S)-3-methyl-1-oxo-1-((1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

参考文献

1. Chen ZF, et al. Brain Res. 1997 Sep 19;769(1):188-92.

2. Li PA, et al. Neurosci Lett. 1998 May 8;247(1):17-20.

3. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22.

MDL28170 (MDL-28170)

生物&药学活性

物理化学性质&存储条件

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MDL28170 (MDL-28170)

生物&药学活性

物理化学性质&存储条件

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