MD102 | TG2 inhibitor | Probechem Biochemicals

Chemical Structure : MD102

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MD102 (MD 102)

货号: PC-21655Not For Human Use, Lab Use Only.

MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines.

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生物&药学活性

MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines.
MD102 exhibits p53 stabilization effect and anticancer effects in the ACHN and Caki-1 RCC cell lines with sulforhodamine B (SRB) GI50 values of 2.15 µM and 1.98 µM, respectively.
MD102 induced apoptosis and disturbance of the interaction between p53 and TG2 through regulating the p53/AKT/mTOR signaling.
MD102 (15 mpk, i.p., 50 mpk p.o.) inhibited ACHN xenograft growth in nude mice.

物理化学性质&存储条件

分子量	389.99
分子式	C13H4BrCl2FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-Bromo-3-fluorophenyl)-5,6-dichloro-1H-benzo[d]imidazole-4,7-dione

参考文献

1. Kim GR, et al. Bioorg Chem. 2023 Dec 25;143:107061.

MD102 (MD 102)

生物&药学活性

物理化学性质&存储条件

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MD102 (MD 102)

生物&药学活性

物理化学性质&存储条件

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