MCUF-42 | GC-B receptor PAM | Probechem Biochemicals

Chemical Structure : MCUF-42

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MCUF-42 (MCUF42)

货号: PC-22560Not For Human Use, Lab Use Only.

MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP).

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生物&药学活性

MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP).
In the absence of CNP, MCUF-42 possesses no cGMP-generating activity in HEK293 GC-B cells.
MCUF-42 is a PAM without agonistic activity.
MCUF-42 binds to human GC-B with KD of 710 nM in SPR assays.
MCUF-42 (1, 5, and 10 µM) enhances the cGMP generation of CNP in human cardiac fibroblasts (HCFs).
MCUF-42 enhances CNP mediated inhibition of HCF proliferation triggered by profibrotic TGFβ1.

物理化学性质&存储条件

分子量	393.33
分子式	C19H18Cl2N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(5-(2,5-dichlorophenyl)furan-2-carbonothioyl)piperidin-4-yl)propanenitrile

参考文献

1. Ma X, et al. PNAS Nexus. 2024 Jun 6;3(6):pgae225.

MCUF-42 (MCUF42)

生物&药学活性

物理化学性质&存储条件

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MCUF-42 (MCUF42)

生物&药学活性

物理化学性质&存储条件

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