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首页-小分子抑制剂&激动剂-Others-Other Targets-MCU-i4
MCU-i4

Chemical Structure : MCU-i4

CAS No.: 371924-24-2

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MCU-i4

货号: PC-73142Not For Human Use, Lab Use Only.

MCU-i4 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.

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100 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MCU-i4 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i4 directly binds a specific cleft in MICU1 (Kd=8.4 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i4 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.

物理化学性质&存储条件

分子量 377.49
分子式 C23H27N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate

参考文献

1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

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