MCL0129 tetrahydrochloride | MC4R antagonist | Probechem Biochemicals

Chemical Structure : MCL0129 tetrahydrochloride

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MCL0129 tetrahydrochloride (MCL-0129 tetrahydrochloride)

货号: PC-61571Not For Human Use, Lab Use Only.

MCL0129 tetrahydrochloride is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.

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生物&药学活性

MCL0129 tetrahydrochloride is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
MCL0129 attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels.
MCL0129 exhibits anxiolytic- and antidepressant-like activities in various rodent models.

物理化学性质&存储条件

分子量	692.607
分子式	C34H51Cl4FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(1-(4-fluorophenyl)-2-(4-(4-(2-methoxynaphthalen-1-yl)butyl)piperazin-1-yl)ethyl)-4-isopropylpiperazine tetrahydrochloride

参考文献

1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26.

2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400.

MCL0129 tetrahydrochloride (MCL-0129 tetrahydrochloride)

生物&药学活性

物理化学性质&存储条件

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MCL0129 tetrahydrochloride (MCL-0129 tetrahydrochloride)

生物&药学活性

物理化学性质&存储条件

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